As the team prepare to make the trip to Old Trafford on Saturday, there is one man who will need no motivation when he takes his place against Manchester United.
It proved to be a special introduction to English football when Adrian was called upon to make his Premier League debut at Old Trafford back in December 2013.
The result did not go West Ham's way as United came away with a 3-1 victory, but for Adrian it was a major turning point in his Hammers career as he cemented his position as the first-choice keeper and has never looked back.
The 28-year-old has quickly become a fans favourite at the Boleyn Ground and has produced some outstanding displays for the Club.
Adrian showed his quality once again last weekend when he made a wonder save to deny a close-range header from Salomon Rondon and help West Ham come away with a point against West Brom.
The talented keeper is now hoping to keep Wayne Rooney and his fellow United team-mates at bay on Saturday and make it another memorable trip to Manchester after the Hammers came away with a 2-1 victory over Manchester City back in September.
Adrian said: “I have good memories of going to Old Trafford and making my debut for the Club.
“We didn't enjoy the best of results but it was amazing for me to my debut against Manchester United. They have a great stadium and I enjoyed the game.
“I have played in some big stadiums in Spain like the Bernabeu and Camp Nou but to make my debut at Old Trafford was amazing and it was unlucky that we could not get a result at that time.
“We have plenty of confidence going to play there and I think we can show a great performance and get a good result.
“We are playing well but sometimes we are a bit unlucky and it was the same against West Brom last weekend. I believe we can get good results if we are playing to our top level.
“It is always disappointing to miss players like Dimitri Payet and Diafra Sakho but we have a good squad of players who can come into the starting eleven. We have many players in attack and I have confidence in all of them.”
Adrian was thrilled to meet up with West Ham legend Ludek Miklosko when he attended the home game against West Brom last week.
The Czech Republic keeper had nothing but praise for the way Adrian has performed following his arrival at the Boleyn Ground and Adrian was honoured to hear such positive comments.
Adrian added: “I am very proud to hear what Ludek said about me. He is a legend for West Ham and I managed to say hello to him for the first time before the West Brom game. He was a great keeper for the Club and is a great person.
“I know the fans have a special song for him and they have some songs for me. I just want to keep playing well and producing my best form.”