West Ham United will travel to Wolverhampton Wanderers in the FA Youth Cup third round on Wednesday 7 December.
The fixture will be played at Wolves' Molineux stadium, with kick-off at 7pm. Tickets will be available to buy on the night.
Tony Carr's youngsters will hope to go further than they did in last season's competition, when they lost 1-0 to eventual winners Manchester United in the fourth round.
West Ham have won the FA Youth Cup on three previous occasions, lifting the trophy in 1963, 1981 and 1999. Wolves, meanwhile, were runners-up in each of the first two editions of the tournament in 1953 and 1954 before lifting the trophy in 1958. They also were also beaten finalists in 1962 and 1976.
Hopes are high that the Hammers can win the prestigious competition for a fourth time, with a talented squad of players performing well under the eye of Carr and U18s coach Nick Haycock.
This year's competition will be the 60th staging, with local side Thurrock hoping to set up a third-round meeting with Blackburn Rovers by beating Hayes & Yeading. Thurrock's second-round meeting with Hayes & Yeading will take place at Ship Lane on Wednesday 23 November at 7.45pm.
Before then, two of West Ham's promising Academy players - Blair Turgott and Matthias Fanimo (pictured) - will take centre-stage when England's Under-18s take on Slovenia in a friendly international this afternoon. Live coverage of the game will be shown on the FA website here.