Tony Stokes, Lee Bowyer, Jordan Spence and Joe Widdowson were all winners on Saturday while Julien Faubert again failed to figure for Real Madrid.
Stokes has moved to Hungarian high-fliers Ujpest until the end of the season and played for 66 minutes on his competitive debut as they drew level on points with leaders Debrecen following a 2-0 home win against Siofok. Peter Rajczi opened the scoring on 51 minutes before Tibor Tisza sealed the victory in the dying seconds.
In the Championship, Bowyer played a full 90 minutes as Birmingham City won 1-0 at home against struggling Southampton thanks to a Keith Fahey goal. It keeps the Blues three points ahead of Wolverhampton Wanderers, who maintained their charge for promotion to the Premier League with a 1-0 win at Sheffield Wednesday. Neither Kyel Reid or Nigel Quashie figured for Wolves.
In League One, Spence has been impressive for Orient since joining in January until the end of the season - his second spell at the Matchroom Stadium. The 18-year-old was back in his more familiar central defensive position on Saturday and, although unable to avoid the opening goal for Brighton and Hove Albion, he helped the team come back to win 2-1 - crucially lifting them out of the drop zone.
Elsewhere, the 19-year-old Joe Widdowson got just under half-an-hour off the bench as Grimsby Town romped to a 5-1 home win against mid-table Lincoln City and move out of the bottom two in League Two.
Over in Spain, Faubert remained on the bench as Madrid failed to make it eleven straight league wins in Spain with a 1-1 draw in the derby with Atletico. Diego Forlan had put Atletico in front seven minutes before the interval before Klaas Jan Huntelaar struck an equaliser close to the hour mark.
In the English top flight, Calum Davenport was also unused substitute as Sunderland were only just denied all three points in a 1-1 draw at home to Tottenham Hotspur after Robbie Keane's late goal cancelled out Kieran Richardson's opener. Finally, goalkeeper Jimmy Walker is back at West Ham United after his successful loan spell at Colchester United came to an end and Jack Jeffery helped Eastbourne Borough to a 1-0 home win against Wrexham in the Blue Square Premier.