In the absence of cover for Fredi Kanoute, and the now injured Paolo Di Canio reducing his striking options still further, the Hammers boss cannot bring in replacements until January.
"It is ironic that, the first year the transfer window has been brought in to play, it has really hurt us," he says, "because there is no doubt about it, once we knew Fredi was going to be out for a long period of time, we would have done something about it now.
"But January 1st is as early as you can take anyone in and transfer windows are not good for clubs that operate with a small senior squad, as we do.
"No one can deny that. The size of our senior squad is easily the smallest in the Premiership."
He fervently hopes that, with Don Hutchison, Steve Lomas, and Richard Gacia all out of the picture as well, no one else gets injured, and says: "We really need all our players fit at the moment; we are coming up to a really tough period in December and we need them all available."
He admits life is tough at the moment, and adds: "It has been a rotten week, starting with Monday night and a game that not only should we not have lost, we should have won it comfortably.
"It was a performance that was good enough to secure a win, but yet again we failed to do so in front of our own supporters.
"That hugely disappoints us, and left us scratching our heads because we should have come off at half time with the job already done - but we didn't.
"The manner in which we lost in injury time really rubs salt into the wound and, to make it a doubly disappointing week, Paolo got injured.
"We need to somehow find the possibility of bringing in one new striker, and in an ideal world I just hope we can find a way of bringing in two."
He is hoping that the fans travelling to Middlesbrough's Riverside Stadium on Saturday can inspire the Hammers and adds: "It is really tough for everyone and I include the fans in that. We all want to support a team that is doing well.
"Now that the true test is upon us we need their support and the travelling fans have always given us magnificent support, so all I hope is that they will do that at the Riverside.
"It will help us, there is no doubt about it, and I hope we can all help ourselves by putting on a winning performance that will make people cheer even louder than they normally do - and keep us going right through the game."
As for the employment of Ian Pearce up front against Southampton, Glenn says: "I felt it worked as well as could be expected. The lad's commitment was there for everyone to see and he worked so hard, giving us the option sometimes, when we can't get the ball into feet, to play the ball in the air.
"He had a real old battle with two big centre backs in Lundekvam and Svensson, and won his fair share of headers.
"And when he flicked a few on you could see that he and Defoe were linking quite well, as Jermain was reading the flicks and getting into dangerous situations.
"Hopefully on Saturday, with Ian playing his second game as a striker, he will be that much more acquainted with the position and give an even better performance.
"And if we can give him the same number of chances that he had on Monday night maybe this time he will finish them off for us.
"In the case of Jermain, everything he does now is all part of his learning curve and a bonus for him. We can now play a big physical striker for him to feed off.
"We have worked hard this week on their partnership of working closely together."