The pair come face to face this weekend at Upton Park though Anelka, one of the world's costliest players, is likely to start on the subs' bench.
However, when asked about whose is the greater talent, Seb goes for Fredi, explaining: "Fredi is a fantastic player who I work with every day, and for me it is him because he is stronger, quicker, and more technical.
"The French people are very strange - sometimes when Anelka scores two or three goals he is the best player in the world, and if he doesn't score for 10 he is supposed to be s***.
"For me he is a very strong player, like Owen, who has maybe three or four chances and gets two or three goals - he is a very dangerous man.
"I'm sure he will play well for Liverpool because he is very quick and that's what you need in this league. He is a very good signing and, although he has big problems in his head, I think he will very much enjoy playing for Liverpool."
Seb is backing Fredi, after a stop-start first half of the season, to put his injury worries behind him now, and he says: "It is just a bad period he is going through and he is working harder than last season; but if he plays all the game against Liverpool I think his problems will be finished."
Seb opened his account in his 29th start for West Ham with the opening goal against Derby - but wasn't certain at first he had scored!
"I didn't have the time to think anything. I listened to the fans and then I was sure I'd scored even though I didn't see the ball go in," he says.
"It was a big surprise; I never score in training either, and that is only my third goal in about 250 games.
"I just want to defend and get some assists for Fredi, Paolo, and Jermain, so the goal was just a little bonus.
"I was very happy for everybody; the goal was important for the start of the game because Glenn knew that Derby could play well.
"I was pleased to score, but I was going into the box just for fun - I never thought the ball would come to my feet.
"I was surprised but happy, and afterwards the team was more relaxed, even though we didn't play very well."
It puts him alongside Steve Potts on one Hammers career goal, and Seb says: "I would prefer to never score and have his career; he is very professional and everybody knows he is a fantastic player.
"When I train with him I understand English football, so I am very pleased to know him."
He adds that he has felt a lot more settled in the second half of 2001, once he signed a permanent deal after initially arriving on loan from Metz.
"The last six months have been fantastic for me because I signed for a big team, I play every game, and I have no problems with the journalists," he says.
"But it is just the beginning. I have a four year contract and I want to improve every day, work hard towards that, and with Glenn I think it is possible.
"Before the summer it was very difficult because I didn't know if I would sign.
"I want to stay here; when you sign for this team you want to play for the fans and I was very happy to sign.
"Maybe I don't play well every game, but I give my best and can now look at the long term.
"If Glenn says he doesn't want me to leave then I won't; I would like to stay beyond my contract because I enjoy playing for this team."
And Glenn says of Sebastien: "I have been really pleased with Sebastien; he certainly plays with his heart on his sleeve, he has got amazing energy, he is up for being coached, and he is ready to learn."