He acknowledges that his opposite number John Gregory has, like himself, many players missing, but insists: "They are evidently carrying a few injuries but, as everyone knows, so are we, so we'll have to see what both teams can put out.
"The fact of the matter is, as many injuries as we have got, it appears that Villa have got more and if we had that number of injuries we wouldn't have the players to go to war with.
"I have seen John Gregory say recently he is down to 16 fit first team players and quite honestly I'd like to be in the same position to be able to say that.
"We operate on probably the smallest first team squad in the Premiership and, as we saw against Spurs, playing without Kanoute, Di Canio, Michael Carrick and Nigel Winterburn makes it very difficult for us to win games that we want to win - we just can't cope with having four players like that out of the team.
"It doesn't mean to say that the boys who have come in haven't done their best, but we can't handle having the quality of those four out of the team all at the same time.
"We have got an excellent physiotherapy team but, in most cases, injuries, when they happen, can't be legislated for and it is taken out of your hands.
"Those are the lucky cards you need and I certainly feel if there is any luck going hopefully it will start to come our way, because I don't feel we have had too much this season - in fact we've had hardly any at all."
Glenn's biggest fear now is being forced to rush people back early and he adds: "It gets to the point where if we pick up any more injuries we will be putting players in that we probably feel aren't quite ready for the Premiership - and you don't want to get in that situation.
"And of course we have lost Steve Lomas until the end of January so things haven't been too brilliant for us just of late as far as the injury front is concerned.
"It is there for everyone to see, you have only to look into the depth of the squad and beyond the first 12 or 13 players to see that we haven't got strength in depth.
"Aston Villa have certainly found themselves in a similar boat and it makes things much tougher, but we must get on with the job and I'm sure that the players who put on the shirt will give their all."
Glenn feels that the loss of Peter Schmeichel is the least of Villa's problems, and adds: "Enckelman is an excellent goalkeeper - David James was convinced that when we brought him he would be the first team choice this year.
"So he comes highly recommended by David, and I'm sure he will be pumped up for the game, because he is obviously not getting too many chances with Schmeichel there.
"We know all about Villa's talent - they have had a couple of disappointing results in the last week but to be honest we have got to pick up the winning thread ourselves."
All the more so, says Glenn, because of the tough fixtures just round the corner.
"We play probably the top four teams this month and we really do need these three points," he says.
"Hopefully we can pick up a win because there is such a difficult month ahead of us.
"Since we had our three match winning run we have only picked up one point in the last four games which has been, to say the very least, disappointing - and we obviously expect a better return."
Glenn says that he is doing what he can to improve the playing squad and adds: "I am working all the hours there are to bring in loan players."
Glenn reckons that the crowd can play their part in roaring the players on to victory against Aston Villa and adds: "It helps when we get a good night time atmosphere at Upton Park and we certainly had that when we played against Chelsea.
"We got a great performance and a great result then, and we want a repeat of that against Aston Villa.
"In recent years games against them have been tight and there have been a lot of draws, but we really must go gunning for those three points tomorrow."